Longevity Intervention Database


Database Top list
Top list
longevity interventions		 Rats
Strain F344		 Rats
Other strains		 Mice
Strain HET3		 Mice
Strain C57BL6		 Mice
Other strains		 Fruit flies
Strain Canton S		 Roundworms
Strain N2		 Roundworms
Other strains
Calorie restriction

Median lifespan:

Maximum lifespan:

 

19%

 

26%

 

13%

 

26%

40%

39%

39%

27%

 

35%

 

16%

65%

42%

51%

24%

 

 

 

 

 

 

 

 

Rapamycin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

28%

22%

21%

11%

7%

14%

19%

8%

77%

17%

117%

18%

 

 

 

 

20%

19%

11%

11%

Rapamycin + Acarbose

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

28%

37%

21%

24%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Doxycycline

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

29%

34%

35%

39%

95%

84%

 

 

Metformin + Rapamycin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

23%

23%

17%

10%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Metformin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

0%

7%

0%

-1%

 

9%

 

0%

 

 

 

 

27%

30%

32%

34%

41%

57%

35%

15%

Rifampicin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

22%

45%

20%

31%

85%

78%

 

 

Captopril

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

5%

14%

8%

7%

 

 

 

 

 

 

 

 

 

 

 

 

48%

46%

 

 

Acarbose

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

5%

22%

8%

12%

 

 

 

 

 

 

 

 

 

 

 

 

30%

7%

11%

5%

Canagliflozin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

1%

14%

4%

10%

 

 

 

 

 

 

 

 

 

 

 

 

21%

45%

 

 

Resveratrol

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

4%

7%

3%

2%

 

 

 

 

 

 

 

 

 

 

 

 

85%

79%

84%

77%

Simvastatin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

4%

4%

4%

3%

 

 

 

 

 

 

 

 

 

 

 

 

68%

51%

 

 

GSK2126458 + Doxycycline

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

109%

102%

 

 

17-a-estradiol

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

2%

19%

0%

12%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Protandim

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

3%

7%

6%

6%

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

GSK2126458 + LY-294002

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

78%

84%

 

 

LY-294002 HCl

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

7%

24%

0%

15%

50%

41%

45%

39%

GSK2126458

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

83%

76%

 

 

Rifampicin + Caffeine

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

92%

75%

 

 

Bacitracin

Median lifespan:

Maximum lifespan:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

12%

74%